{"id":2871,"date":"2025-04-27T09:25:28","date_gmt":"2025-04-27T16:25:28","guid":{"rendered":"https:\/\/wrwofficial.com\/index.php\/2025\/04\/27\/immunotherapy-drug-spares-cancer-patients-from-grisly-surgeries-and-harsh-therapies\/"},"modified":"2025-04-27T09:25:31","modified_gmt":"2025-04-27T16:25:31","slug":"immunotherapy-drug-spares-cancer-patients-from-grisly-surgeries-and-harsh-therapies","status":"publish","type":"post","link":"https:\/\/wrwofficial.com\/index.php\/2025\/04\/27\/immunotherapy-drug-spares-cancer-patients-from-grisly-surgeries-and-harsh-therapies\/","title":{"rendered":"Immunotherapy Drug Spares Cancer Patients From Grisly Surgeries and Harsh Therapies"},"content":{"rendered":"<p><\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">When a person develops solid tumors in the stomach or esophagus or rectum, oncologists know how to treat them. But the cures often come with severe effects on quality of life. That can include removal of the stomach or bladder, a permanent colostomy bag, radiation that makes patients infertile and lasting damage from chemotherapy.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">So a research group at Memorial Sloan Kettering Cancer Center, using a drug from the pharmaceutical company GSK, tried something different.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The researchers started with a group of 103 people. The trial participants were among the 2 to 3 percent of cancer patients with tumors that should respond to immunotherapy, a drug that overcomes barriers that prevent the immune system from attacking cancers.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">But in clinical trials, immunotherapy is not supposed to replace the standard treatments. The researchers, led by Dr. Luis A. Diaz Jr. and Dr. Andrea Cercek, decided to give <a class=\"css-yywogo\" href=\"https:\/\/www.jemperlihcp.com\/?cc=ps_URB1EFKZME2461058&amp;mtrc=240012&amp;mcm=240012&amp;gad_source=1&amp;gad_campaignid=21607606479&amp;gbraid=0AAAAACUY6raNQGmtKNPqxUXD9_68gN_zt&amp;gclid=Cj0KCQjw5azABhD1ARIsAA0WFUEsfdtoNrkFWkDRZPh_q43pIIPf3LuDXkN3l44zhqM1ZzZSazPpEOcaAgF9EALw_wcB&amp;gclsrc=aw.ds\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">dostarlimab<\/a>, an immunotherapy drug, on its own.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The result was stunning, and could bring hope to the limited cohort of patients contending with these cancers.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">In 49 of the patients, who had rectal cancer, the tumors disappeared and, after five years, have not recurred. Cancers also vanished for 35 of 54 patients who had other cancers, including in the stomach, esophagus, liver, endometrium, urinary tract and prostate.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Out of all 103 patients, cancers recurred in only five. Three got additional doses of immunotherapy and one, whose tumor recurred in a lymph node, had the lymph node removed. Those four patients so far have no evidence of disease. The fifth patient had additional immunotherapy that made the tumor shrink.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The investigators reported their results Sunday at the annual meeting of the American Association for Cancer Research and in a <a class=\"css-yywogo\" href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2404512\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">paper<\/a> published in The New England Journal of Medicine.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The results, said Dr. Bert Vogelstein, an oncologist at Johns Hopkins in Baltimore, are \u201cgroundbreaking.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-2\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Earlier phases of the drug\u2019s development occurred in his lab, and he has watched its progress with amazement.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cTwenty or 30 years ago, the idea that you could take large tumors of many different organs and treat them without doing surgery would seem like science fiction,\u201d he said. But, he added, the discovery did not spring full blown into the minds of researchers. Instead, he noted, it builds on 40 years of research \u201cstarting with very basic science.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The reason immunotherapy even had a chance against these large tumors is because the patients\u2019 tumors had what is known as mismatch repair mutations in their genes that prevented them from fixing DNA damage. As a result, such tumors are studded with unusual proteins that signal the immune system to destroy them. But tumors put up a shield that blocks immune system attacks. Immunotherapy pierces the shield and allows the immune system to destroy the tumors.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">For patients like those in the study, said Dr. Michael Overman, a specialist in gastrointestinal cancer at MD Anderson Cancer Center in Houston, the results show immunotherapy without chemotherapy, radiation treatments or surgeries is a valid treatment \u201cand it is so logical we should be doing it.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">But, for now, that may not be so easy. The drug costs about $11,000 per dose, and patients need nine infusions over six months. In order to get insurance coverage, the drug has to be included in clinical guidelines, sets of recommendations for treatments produced by professional organizations.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">It is approved as a treatment for uterine cancers with mismatch repair mutations and is included in clinical guidelines for the treatment of rectal cancer, based on an earlier small <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2022\/06\/05\/health\/rectal-cancer-checkpoint-inhibitor.html\" title=\"\">study<\/a>. But patients with other cancers might have trouble getting the drug, Dr. Diaz said. Memorial Sloan Kettering, though, is still recruiting for its clinical trial, so patients who have tumors with mismatched repair mutations and qualify for the study can get the drug free.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">For some patients, immunotherapy has been miraculous. It can have side effects \u2014 the most common among patients in the study were fatigue, rash and itching. Rarer side effects included lung infections and encephalitis.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Maureen Sideris, 71, of Amenia, N.Y., found out she had cancer after she tried to eat a hamburger.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cIt would not go down,\u201d she said. There was some sort of blockage. It turned out to be a tumor at the juncture of her stomach and esophagus.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">She went to Sloan Kettering in 2019. Her surgeon told her that she needed surgery, chemotherapy and radiation and that the surgery would be difficult \u2014 they might have to take out a piece of her stomach and move her esophagus<\/p>\n<p class=\"css-at9mc1 evys1bk0\">But her tumor had a mismatch repair mutation, so she joined the clinical trial. The first infusion was on Oct. 14 of that year. By January, her tumor was gone. Ms. Sideris has one side effect from the treatment \u2014 she needs to take medication now to improve how her kidneys function. But she says it is worth paying that price to avoid the onerous treatment that would have been in store for her.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-4\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cIt\u2019s been a journey,\u201d she said. But, she added, she reasoned that she had nothing to lose when she agreed to try immunotherapy.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cI still had surgery as a backup if it didn\u2019t work,\u201d she said.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n","protected":false},"excerpt":{"rendered":"<p>When a person develops solid tumors in the stomach or esophagus or rectum, oncologists know how to treat them. But the cures often come with severe effects on quality of life. That can include removal of the stomach or bladder, a permanent colostomy bag, radiation that makes patients infertile and lasting damage from chemotherapy. So [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2872,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[327],"tags":[366,364,368,370,363,367,365,369,371],"class_list":{"0":"post-2871","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-cancer","9":"tag-drug","10":"tag-grisly","11":"tag-harsh","12":"tag-immunotherapy","13":"tag-patients","14":"tag-spares","15":"tag-surgeries","16":"tag-therapies"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.0 (Yoast SEO v26.0) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Immunotherapy Drug Spares Cancer Patients From Grisly Surgeries and Harsh Therapies - Well Rooted Wellness<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wrwofficial.com\/index.php\/2025\/04\/27\/immunotherapy-drug-spares-cancer-patients-from-grisly-surgeries-and-harsh-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunotherapy Drug Spares Cancer Patients From Grisly Surgeries and Harsh Therapies\" \/>\n<meta property=\"og:description\" content=\"When a person develops solid tumors in the stomach or esophagus or rectum, oncologists know how to treat them. 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