{"id":3419,"date":"2025-05-30T15:31:00","date_gmt":"2025-05-30T22:31:00","guid":{"rendered":"https:\/\/wrwofficial.com\/index.php\/2025\/05\/30\/can-this-nasal-spray-slow-down-alzheimers-one-couple-is-helping-scientists-find-out-shots\/"},"modified":"2025-05-30T15:31:05","modified_gmt":"2025-05-30T22:31:05","slug":"can-this-nasal-spray-slow-down-alzheimers-one-couple-is-helping-scientists-find-out-shots","status":"publish","type":"post","link":"https:\/\/wrwofficial.com\/index.php\/2025\/05\/30\/can-this-nasal-spray-slow-down-alzheimers-one-couple-is-helping-scientists-find-out-shots\/","title":{"rendered":"Can this nasal spray slow down Alzheimer&#8217;s? One couple is helping scientists find out : Shots"},"content":{"rendered":"<p><\/p>\n<div id=\"storytext\">\n<div id=\"resg-s1-69250\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 4000;&#10;        --source-height: 2667;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F20%2Fc2%2F3eea67aa477dbf655b2d762c06fc%2Fjdh05133.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/jpeg\"\/><\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                Joe Walsh, who has Alzheimer&#8217;s disease, is accompanied by his wife, Karen Walsh, to an appointment at Brigham and Women&#8217;s Hospital in Boston. Joe is receiving an experimental therapy to treat Alzheimer&#8217;s.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    Jodi Hilton\/for NPR\u200e<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        Jodi Hilton\/for NPR\u200e<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>Joe Walsh, 79, is waiting to inhale.<\/p>\n<p>He&#8217;s perched on a tan recliner at the Center for Alzheimer Research and Treatment at Brigham and Women&#8217;s Hospital in Boston. His wife, Karen Walsh, hovers over him, ready to depress the plunger on a nasal spray applicator.<\/p>\n<p>&#8220;One, two, three,&#8221; a nurse counts. The plunger plunges, Walsh sniffs, and it&#8217;s done.<\/p>\n<p>The nasal spray contains an experimental monoclonal antibody meant to reduce the Alzheimer&#8217;s-related inflammation in Walsh&#8217;s brain.<\/p>\n<p>He is the first person living with Alzheimer&#8217;s to get the treatment, which is also being tested in people with diseases including multiple sclerosis, ALS and COVID-19.<\/p>\n<aside id=\"ad-backstage-wrap\" class=\"ad-wrap backstage\" aria-label=\"advertisement\">\n<\/aside>\n<p><!-- END ID=\"RESNX-S1-5407860-100\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>And the drug appears to be reducing the inflammation in Walsh&#8217;s brain, researchers report in the journal <em>Clinical Nuclear Medicine<\/em>.<\/p>\n<p>&#8220;I think this is something special,&#8221; says Dr. Howard Weiner, a neurologist at Mass General Brigham who helped develop the nasal spray, along with its maker, Tiziana Life Sciences.<\/p>\n<p>Whether a decrease in inflammation will bring improvements in Walsh&#8217;s thinking and memory, however, remains unclear.<\/p>\n<div id=\"resnx-s1-5407860-101\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage1182881226\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2023\/06\/19\/1182881226\/huntingtons-spreads-like-fire-in-the-brain-alzheimers-parkinsons\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/health-shots\/2023\/06\/19\/1182881226\/huntingtons-spreads-like-fire-in-the-brain-alzheimers-parkinsons&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s=100&amp;c=85&amp;f=png\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s=100&amp;c=100&amp;f=png\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s=100&amp;c=85&amp;f=png\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s=100&amp;c=100&amp;f=png\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"png\" class=\"img lazyOnLoad\" type=\"image\/png\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s=100&amp;c=100&amp;f=png\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2023\/06\/16\/polyq_image1_sq-bb52016cdf230bab7225588ef494651d9a343fd0.png?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"png\" class=\"img lazyOnLoad\" alt=\"Huntington's spreads like 'fire in the brain.' Scientists say they've found the spark\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5407860-101\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>The experimental treatment is part of a larger effort to find new ways to interrupt the cascade of events in the brain that lead to Alzheimer&#8217;s dementia.<\/p>\n<p>Two drugs now on the market clear the brain of sticky amyloid plaques, clumps of toxic protein that accumulate between neurons. Other experimental drugs have targeted the tau tangles, a different protein that builds up inside nerve cells.<\/p>\n<p>But fewer efforts have tried to address inflammation, a sign of Alzheimer&#8217;s that becomes more pronounced as the disease progresses.<\/p>\n<div id=\"resg-s1-69251\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 4000;&#10;        --source-height: 2667;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1100\/quality\/50\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F2e%2F58%2F96e7b14043199802c5bf58ef8f15%2Fjh205695.jpg\" class=\"img\" alt=\"Joe Walsh, who suffers from Alzheimer\u2019s Disease, is tested by Dr. Brahyan J. Galindo-Mendez at Mass General Brigham Hospital in Boston, Mass.\" loading=\"lazy\"\/>\n        <\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                Dr. Brahyan Galindo-Mendez, right, administers an eye-tracking test to Walsh after his treatment.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    Jodi Hilton\/\u200efor NPR<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        Jodi Hilton\/\u200efor NPR<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<h3 class=\"edTag\">A diagnosis and a quest for care<\/h3>\n<p>Once Joe Walsh has finished inhaling the experimental medication, he gets a cognitive exam from Dr. Brahyan Galindo-Mendez, a neurology fellow.<\/p>\n<p>&#8220;Can you tell me your name please,&#8221; Mendez asks. &#8220;What&#8217;s your name?&#8221;<\/p>\n<p>After a pause, Walsh answers: &#8220;Joe.&#8221;<\/p>\n<div id=\"resnx-s1-5407860-102\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage1113825311\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2022\/08\/01\/1113825311\/alzheimers-researchers-are-looking-beyond-plaques-and-tangles-for-new-treatments\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/health-shots\/2022\/08\/01\/1113825311\/alzheimers-researchers-are-looking-beyond-plaques-and-tangles-for-new-treatments&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/07\/29\/ap20036780142644_sq-0d2c50bb1f86e2d3636d661d03eb3ed5ef15175e.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"Alzheimer's researchers are looking beyond plaques and tangles for new treatments\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5407860-102\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>&#8220;And who is with you today?&#8221; Mendez says, glancing toward Walsh&#8217;s wife, Karen.<\/p>\n<p>&#8220;We&#8217;ll do that,&#8221; Walsh replies.<\/p>\n<p>&#8220;What&#8217;s her name?&#8221; Mendez persists.<\/p>\n<p>&#8220;Her name,&#8221; Walsh echoes. &#8220;That&#8217;s her name. That&#8217;s my wife.&#8221;<\/p>\n<p>Walsh is unable to put a name to the woman he&#8217;s been married to for 36 years.<\/p>\n<div id=\"resg-s1-69255\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 4000;&#10;        --source-height: 2667;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1100\/quality\/50\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F60%2Fc2%2F6db13f9746019fd8b0793721fbc8%2Fjh205742.jpg\" class=\"img\" alt=\"In 2019, a PET scan confirmed that Joe Walsh had Alzheimer\u2019s. It took Karen Walsh years to get her husband into a research study that would offer him an experimental treatment.\" loading=\"lazy\"\/>\n        <\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                In 2019, a PET scan confirmed that Joe Walsh had Alzheimer&#8217;s. It took Karen Walsh years to get her husband into a research study that would offer him an experimental treatment.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    Jodi Hilton\/for NPR<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        Jodi Hilton\/for NPR<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>Karen Walsh began to notice a change in her husband back in 2017.<\/p>\n<p>&#8220;He was struggling to find the right words to complete a thought or a sentence,&#8221; she says.<\/p>\n<p>The couple went to a primary care doctor, who said that if Walsh turned out to have Alzheimer&#8217;s, he should enter a research study in hopes of getting one of the latest treatments. Then the doctor referred Walsh to a neurologist.<\/p>\n<div id=\"resnx-s1-5407860-103\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage1121848232\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2022\/09\/12\/1121848232\/early-alzheimers-gene-test-experimental-treatment\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/health-shots\/2022\/09\/12\/1121848232\/early-alzheimers-gene-test-experimental-treatment&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/09\/09\/alzheimers-gene-2_sq-b2a5082e8c2c01eedf3feb78b68b3b92276c2854.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"With early Alzheimer's in the family, these sisters decided to test for the gene\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5407860-103\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>In 2019, a PET scan revealed extensive amyloid plaques in Walsh&#8217;s brain, confirming the diagnosis.<\/p>\n<p>&#8220;As much as I was in shock,&#8221; Karen Walsh says, &#8220;the words were ringing in my head: &#8216;ask for the research.'&#8221;<\/p>\n<p>So she began looking for a clinical trial. But in 2020, COVID arrived in the U.S., shuttering hundreds of research studies. By the time the pandemic subsided, Walsh&#8217;s Alzheimer&#8217;s had progressed to the point where he no longer qualified for most studies.<\/p>\n<h3 class=\"edTag\">A novel drug for inflammation<\/h3>\n<p>In late 2024, Karen brought Joe to Dr. Seth Gale, a neurologist at Mass General Brigham and Harvard Medical School who promised to look for a research study Walsh could enter.<\/p>\n<aside id=\"ad-secondary-wrap\" class=\"ad-wrap secondary\" aria-label=\"advertisement\">\n<\/aside>\n<p>Before long, Gale received a query from a colleague looking for a patient with moderate Alzheimer&#8217;s disease to take part in a trial. He called the Walshes.<\/p>\n<p>The research involved a monoclonal antibody called foralumab that was being tested on people with inflammatory diseases including multiple sclerosis.<\/p>\n<div id=\"resg-s1-69256\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 4000;&#10;        --source-height: 2667;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 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30px)\" class=\"img\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1100\/quality\/50\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F4c%2Fcb%2F9757b41b41019b1023efc25ec96f%2Fjh205632.jpg\" class=\"img\" alt=\"Foralumab nasal spray, above, is being tested as a treatment for Alzheimer\u2019s disease by researchers at Mass General Brigham.\" loading=\"lazy\"\/>\n        <\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                Foralumab nasal spray, above, is being tested as a treatment for Alzheimer&#8217;s disease by researchers at Mass General Brigham.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    Jodi Hilton\/for NPR<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        Jodi Hilton\/for NPR<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>MS occurs when the immune system mistakenly attacks the protective covering around nerve fibers, causing inflammation. And foralumab was producing promising results in MS patients.<\/p>\n<p>&#8220;It induces regulatory cells that go to the brain and shut down inflammation,&#8221; Weiner says.<\/p>\n<p>Those regulatory cells reduce the activity of microglia, the cells that serve as the primary immune system in the brain and spinal cord.<\/p>\n<p>Weiner thought foralumab might help with another condition that causes damaging inflammation in the nervous system.<\/p>\n<p>&#8220;I&#8217;ve always been interested in Alzheimer&#8217;s disease,&#8221; Weiner says. &#8220;I lost my mother to Alzheimer&#8217;s disease.&#8221;<\/p>\n<p>Most efforts to treat Alzheimer&#8217;s involve clearing the brain of the disease&#8217;s hallmarks: sticky amyloid plaques and tangled fibers called tau. But increasingly, researchers are seeking ways to tamp down the inflammation that accompanies those brain changes, especially as the disease progresses.<\/p>\n<p>&#8220;Once people have Alzheimer&#8217;s, the inflammation is driving the disease more,&#8221; Weiner says.<\/p>\n<div id=\"resg-s1-69259\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 4000;&#10;        --source-height: 2667;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 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30px)\" class=\"img\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1100\/quality\/50\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1d%2Fcf%2Fb9f3e01a4302a776ff876bf850d2%2Fjh205907.jpg\" class=\"img\" alt=\"Dr. Howard Weiner, wearing a white coat and glasses, sits in front of a computer with his hands folded on the desk.\" loading=\"lazy\"\/>\n        <\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                Dr. Howard Weiner, a neurologist at Mass General Brigham, is studying foralumab for treating diseases including multiple sclerosis, COVID, ALS and Alzheimer&#8217;s.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    Jodi Hilton\/for NPR\u200e<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        Jodi Hilton\/for NPR\u200e<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>The approach worked in mice that develop a form of Alzheimer&#8217;s.<\/p>\n<p>But in order to treat Walsh, Weiner&#8217;s team had to get special permission from the Food and Drug Administration through a program called expanded access. The program is for patients who can&#8217;t get into a clinical trial and have no other treatment options.<\/p>\n<p>When the FDA approved foralumab for Walsh, he became the first Alzheimer&#8217;s patient to get the treatment.<\/p>\n<p>Six months later, the drug has dramatically reduced the inflammation in Walsh&#8217;s brain. But no drug can restore brain cells that have already been lost.<\/p>\n<p>It will take a battery of cognitive tests to see if Walsh&#8217;s memory and thinking have improved with the treatment. Karen Walsh, though, sees some positive signs.<\/p>\n<aside id=\"ad-third-wrap\" class=\"ad-wrap third\" aria-label=\"advertisement\">\n<\/aside>\n<p>Although her husband still struggles to find words, she says, he appears to be more engaged in social activities.<\/p>\n<p>&#8220;A couple of guys come pick him up once a month, you know, and they take him out for lunch,&#8221; she says. &#8220;They sent me a text after saying, &#8216;Wow, Joe is really, really laughing, and very involved.'&#8221;<\/p>\n<div id=\"resg-s1-69270\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 4000;&#10;        --source-height: 2667;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 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30px)\" class=\"img\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/1100\/quality\/50\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/4000x2667+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Ff0%2F0c%2F6dbb83f14cc18d79283629fa3bb0%2Fjh205873-1.jpg\" class=\"img\" alt=\"After three months of treatment, A PET scan showed that the inflammation in Walsh\u2019s brain had decreased dramatically.\" loading=\"lazy\"\/>\n        <\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                After three months of treatment, a PET scan showed that the inflammation in Walsh&#8217;s brain had decreased dramatically.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    Jodi Hilton\/for NPR\u200e<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        Jodi Hilton\/for NPR\u200e<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>Walsh himself seems happy to stay on the drug. Between non sequiturs, he manages to put together a complete sentence: &#8220;It&#8217;s easy enough to take it, so I do it, and it feels good.&#8221;<\/p>\n<p>A clinical trial of foralumab for Alzheimer&#8217;s disease is scheduled to begin later this year. <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Joe Walsh, who has Alzheimer&#8217;s disease, is accompanied by his wife, Karen Walsh, to an appointment at Brigham and Women&#8217;s Hospital in Boston. Joe is receiving an experimental therapy to treat Alzheimer&#8217;s. Jodi Hilton\/for NPR\u200e hide caption toggle caption Jodi Hilton\/for NPR\u200e Joe Walsh, 79, is waiting to inhale. He&#8217;s perched on a tan recliner [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3420,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[327],"tags":[481,894,896,418,892,895,411,893,706],"class_list":{"0":"post-3419","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-alzheimers","9":"tag-couple","10":"tag-find","11":"tag-helping","12":"tag-nasal","13":"tag-scientists","14":"tag-shots","15":"tag-slow","16":"tag-spray"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.0 (Yoast SEO v26.0) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Can this nasal spray slow down Alzheimer&#039;s? 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