{"id":4535,"date":"2025-09-26T11:53:08","date_gmt":"2025-09-26T18:53:08","guid":{"rendered":"https:\/\/wrwofficial.com\/index.php\/2025\/09\/26\/leucovorin-for-autism-many-scientists-and-parents-are-skeptical-shots\/"},"modified":"2025-09-26T11:53:16","modified_gmt":"2025-09-26T18:53:16","slug":"leucovorin-for-autism-many-scientists-and-parents-are-skeptical-shots","status":"publish","type":"post","link":"https:\/\/wrwofficial.com\/index.php\/2025\/09\/26\/leucovorin-for-autism-many-scientists-and-parents-are-skeptical-shots\/","title":{"rendered":"Leucovorin for autism? Many scientists \u2014 and parents \u2014 are skeptical : Shots"},"content":{"rendered":"<p><\/p>\n<div id=\"storytext\">\n<div id=\"resg-s1-90405\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 8640;&#10;        --source-height: 5760;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/400\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/900\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/1200\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/1600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/1800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8640x5760+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F6e%2F11%2Fbdfea5c94178856637a7e186a82e%2Fgettyimages-2236805445.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/jpeg\"\/><\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                The Trump administration has suggested that leucovorin, a drug used in cancer treatment, might have some benefit for children with autism. Many researchers and families aren&#8217;t so sure.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    Andrew Harnik\/Getty Images<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        Andrew Harnik\/Getty Images<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>President Trump is promising a new treatment for autism spectrum disorder: a prescription form of vitamin B9 called <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/leucovorin-oral-route-intravenous-route-injection-route\/description\/drg-20064503\" target=\"_blank\"><u>leucovorin<\/u><\/a>.<\/p>\n<p>But many scientists and medical organizations are skeptical; some families are excited, and many are wary.<\/p>\n<p>&#8220;I think that this entire thing has been a bit misleading,&#8221; says Caitee Donovan, referring to a White House press conference Monday in which Trump and his deputies blamed Tylenol for autism and encouraged the use of leucovorin to treat it.<\/p>\n<aside id=\"ad-backstage-wrap\" class=\"ad-wrap backstage\" aria-label=\"advertisement\">\n<\/aside>\n<div id=\"resnx-s1-5552751-100\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage1231104444\" href=\"https:\/\/www.npr.org\/2025\/02\/13\/1231104444\/the-anti-vaccine-movement\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/2025\/02\/13\/1231104444\/the-anti-vaccine-movement&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2025\/02\/12\/square-ep-art-template-a_sq-6ff86a0c13af33e70c31266aaa3a6bd06fa7d1a6.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"The Anti-Vaccine Movement\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5552751-100\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>Donovan&#8217;s daughter, Scarlett Donovan-New, was diagnosed with autism at 17 months. Donovan, who lives in Mahopec, N.Y., said she was dismayed to hear the president and several high-level health officials extol the benefits of the medication, which is also known as folinic acid.<\/p>\n<p>It&#8217;s &#8220;an exciting therapy that may benefit large numbers of children who have suffered from autism,&#8221; Health and Human Services Secretary Robert F. Kennedy Jr. said at the event<strong>. <\/strong>The treatment &#8220;gives hope to the many parents with autistic children,&#8221; Trump said.<\/p>\n<div id=\"resnx-s1-5552751-101\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage132703314\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2011\/01\/06\/132703314\/study-linking-childhood-vaccine-and-autism-was-fraudulent\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/health-shots\/2011\/01\/06\/132703314\/study-linking-childhood-vaccine-and-autism-was-fraudulent&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/blogs\/health\/images\/2010\/02\/mmr_sq-1d6eb0eb524a8da0653716eed6e307b1740bd8a2.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"Study Linking Childhood Vaccine And Autism Was Fraudulent\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5552751-101\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>What the Trump administration is offering is a new label on an old product, sanctioning its use for a rare brain condition called <a href=\"https:\/\/rarediseases.org\/rare-diseases\/cerebral-folate-deficiency\/\" target=\"_blank\"><u>cerebral folate deficiency<\/u><\/a> (CFD). The condition&#8217;s connection to autism remains unclear; a minority of people with autism also have CFD.<\/p>\n<p>Parents like Donovan say the move is just another misguided effort to find a simple solution to a complex disorder, and to suggest that parents could have prevented their child&#8217;s autism.<\/p>\n<div id=\"resnx-s1-5552751-102\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImagenx-s1-5551228\" href=\"https:\/\/www.npr.org\/sections\/shots-health-news\/2025\/09\/23\/nx-s1-5551228\/acetaminophen-tylenol-autism-trump-explainer\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/shots-health-news\/2025\/09\/23\/nx-s1-5551228\/acetaminophen-tylenol-autism-trump-explainer&quot;}\"><picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3674x3674+950+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fe4%2Fe4%2F13a2e2c34233824199229ca5b960%2Fgettyimages-2236788598.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"The Trump administration has linked use of the painkiller acetaminophen during pregnancy to autism. Here's what the science, and doctors, have to say about it.\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5552751-102\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<h3 class=\"edTag\">A nuanced understanding of autism\u00a0<\/h3>\n<p>Donovan knows well the stresses that many parents of children with autism face. She says when her toddler was diagnosed, &#8220;we were told she would never speak.&#8221;<\/p>\n<p>&#8220;A direct quote from the doctor: We&#8217;d &#8216;be lucky if she banged her head against a wall,'&#8221; Donovan recalls. &#8220;That&#8217;s what we were told.&#8221;<\/p>\n<p>But now, nine years later, her daughter is thriving.<\/p>\n<p>&#8220;She plays flag football. She did cheer for four years. She talks non-stop,&#8221; Donovan says.<\/p>\n<aside id=\"ad-secondary-wrap\" class=\"ad-wrap secondary\" aria-label=\"advertisement\">\n<\/aside>\n<p>And says it wasn&#8217;t any drug, but years of therapies \u2014 for speech, movement, behavior and even eating \u2014 that helped.<\/p>\n<div id=\"resnx-s1-5552751-103\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImagenx-s1-5550153\" href=\"https:\/\/www.npr.org\/sections\/shots-health-news\/2025\/09\/22\/nx-s1-5550153\/trump-rfk-autism-tylenol-leucovorin-pregnancy\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/shots-health-news\/2025\/09\/22\/nx-s1-5550153\/trump-rfk-autism-tylenol-leucovorin-pregnancy&quot;}\"><picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/678x678+174+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F1b%2Fc6%2F372cb4a34ddc9c008189a3f0f42c%2Fgettyimages-2236812064.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"President Trump stands at the microphone at the White House in front of a shelf of books.\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5552751-103\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>Donovan now understands autism is complex, with roots mostly in genetics. But she spent years agonizing whether something she did \u2014 or didn&#8217;t do \u2014 might have caused the condition. She says that now she knows better.<\/p>\n<p>&#8220;It isn&#8217;t something I did,&#8221; Donovan says. &#8220;This is just who my daughter is and she&#8217;s perfect the way she is.&#8221;<\/p>\n<p>Jax Bayne, an advocate with autism living in Bellingham, Wash., echoed those sentiments.<\/p>\n<div id=\"resnx-s1-5552751-104\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage132857528\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2011\/01\/12\/132857528\/journal-claims-profit-motive-helped-fuel-autism-vaccine-scare\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/health-shots\/2011\/01\/12\/132857528\/journal-claims-profit-motive-helped-fuel-autism-vaccine-scare&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2011\/01\/12\/syringe_sq-e6d3e33df9115c7c2e413e2b955a1c0f9ad92dcb.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"Journal: Profit Motive Helped Fuel Autism-Vaccine Scare\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5552751-104\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>&#8220;I think anybody who&#8217;s excited about the idea of a treatment or cure for autism has literally no idea or understanding of what autism is,&#8221; says Bayne, 35.<\/p>\n<p>Most scientists and medical groups agree that autism has many causes.<\/p>\n<p>Genetic factors are the leading contributor and the best understood, they say.<\/p>\n<p>&#8220;We know now that there are 100 or more autism genes, and we estimate there&#8217;s probably about 400,&#8221; says <a href=\"https:\/\/sebatlab.org\/jonathan-sebat\" target=\"_blank\"><u>Jonathan Sebat<\/u><\/a>, who directs the Beyster Center for Psychiatric Genomics at the University of California, San Diego.<\/p>\n<p>The role of other factors \u2014 like environmental toxins, events that occur during pregnancy, or cerebral folate deficiency \u2014 is still unclear.<\/p>\n<p>But vaccines, which Trump invokes frequently, have been ruled out as a cause of autism.<\/p>\n<h3 class=\"edTag\">The case for leucovorin<\/h3>\n<p>Until now, leucovorin has been prescribed primarily to protect healthy cells from the toxic effects of methotrexate, a common chemotherapy drug used in cancer care. It was approved for this use in 1983.<\/p>\n<p>Now \u2014 at the behest of Trump and with no formal review \u2014 the FDA is <a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-takes-action-make-treatment-available-autism-symptoms\" target=\"_blank\"><u>in the process<\/u><\/a> of changing the product&#8217;s label. The change will include language indicating that leucovorin can &#8220;improve certain symptoms in adults and pediatric patients with cerebral folate deficiency,&#8221; according to an <a href=\"https:\/\/public-inspection.federalregister.gov\/2025-18510.pdf\" target=\"_blank\"><u>FDA document<\/u><\/a> published in the Federal Register.<\/p>\n<p>Cerebral folate deficiency (CFD) is a rare condition in which a person&#8217;s brain isn&#8217;t getting enough vitamin B9. CFD typically appears before age 2, causing a range of symptoms including intellectual disability, lack of muscle control, and seizures. Some of the symptoms overlap those of autism spectrum disorder.<\/p>\n<aside id=\"ad-third-wrap\" class=\"ad-wrap third\" aria-label=\"advertisement\">\n<\/aside>\n<p>One scientific review of a very limited range of studies <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8622150\/\" target=\"_blank\"><u>found<\/u><\/a> that 38% of people with autism had antibodies that can lead to CFD. The same review found that treatment with leucovorin &#8220;significantly improved communication&#8221; in some autistic individuals.<\/p>\n<p>Reviews like this one, which combine data from multiple studies, are prone to bias and are only as good as the underlying research they include.<\/p>\n<p>Also, the potential impact of leucovorin treatment will remain uncertain until scientists establish how many people on the spectrum have CFD, and whether the condition actually causes autism.<\/p>\n<p>CFD occurs when folate, which is important to brain development and function, is unable to reach cells in the brain. Diagnosis requires a spinal tap to measure levels of a form of folate in spinal fluid.<\/p>\n<p>The condition can be caused by genetic mutations or metabolic disorders. But usually the cause is a misguided immune response that keeps folate from entering brain cells.<\/p>\n<p>Leucovorin is a form of folate that can get around those roadblocks.<\/p>\n<p>&#8220;It&#8217;s a bit tough to get really, really excited about what they would call a &#8216;miracle drug,'&#8221; says Shelby Smith, a Dallas mother of a 6-year-old autistic son who is considered non-verbal. Parents, she says, are accustomed to being peddled vitamins, supplements, and even fake therapies. &#8220;It&#8217;s always something being pushed,&#8221; Smith says, which can at times then make symptoms worse.<\/p>\n<p>In infants, leucovorin is most effective when given soon after CFD appears, which can be as early as six months of age, according to the National Organization for Rare Disorders.<\/p>\n<p>The treatment&#8217;s efficacy in older children or adults with autism is uncertain. But the existing research suggests any benefit will be modest.<\/p>\n<p>For example, a recent 24-week <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00431-024-05762-6\" target=\"_blank\"><u>study<\/u><\/a> in India compared 39 autistic children who got leucovorin with 38 who got a placebo.<\/p>\n<p>Both groups raised their scores on a common autism rating scale, which runs from a low of 15 to a high of 60. The children who received the drug improved slightly more than those who didn&#8217;t (3.6 points vs. 2.4).<\/p>\n<aside id=\"ad-overflow-3-wrap\" class=\"ad-wrap overflow-3\" aria-label=\"advertisement\">\n<\/aside>\n<p>In a 12-week <a href=\"https:\/\/www.nature.com\/articles\/mp2016168\" target=\"_blank\"><u>study<\/u><\/a> of 48 autistic children done in Little Rock, Arkansas, in 2013, researchers reported that those who got leucovorin improved significantly on a measure of language impairment, while those who got a placebo did not.<\/p>\n<p>Interestingly, the drug seemed to improve language scores even in children who did not appear to have cerebral folate deficiency.<\/p>\n<p>When the results were published in 2016 in the journal <em>Molecular Psychiatry<\/em>, the authors cautioned that their findings &#8220;should be considered preliminary until treatment is assessed in larger multicenter studies with longer duration.&#8221;<\/p>\n<h3 class=\"edTag\">&#8220;Jumping the gun&#8221;<strong>\u00a0<\/strong><\/h3>\n<p>Given the lack of conclusive evidence, many doctors and researchers think it&#8217;s too soon to be suggesting leucovorin as a treatment.<\/p>\n<p>Medical and scientific groups say they&#8217;d like to see the same sort of research on leucovorin that the FDA requires of other drugs: two large, rigorous clinical trials showing that the product lives up to its label.<\/p>\n<p>The Coalition of Autism Scientists issued a <a href=\"https:\/\/www.coalitionofautismscientists.org\/\" target=\"_blank\"><u>statement<\/u><\/a> saying, &#8220;It is premature to claim that leucovorin is an effective treatment for autism.&#8221;<\/p>\n<p><a href=\"https:\/\/autismsciencefoundation.org\/teams\/dr-alycia-halladay\/\" target=\"_blank\"><u>Alycia Halladay<\/u><\/a>, a biopsychologist and chief science officer of the Autism Science Foundation, agreed.<\/p>\n<p>&#8220;They are jumping the gun a little bit,&#8221; she says.<\/p>\n<p>Halladay is a doctor, parent of a daughter with autism, and chief scientific officer of the Autism Science Foundation. She says the administration is bypassing normal research and safety checks with leucovorin.<\/p>\n<p>&#8220;I don&#8217;t think most people understand the rigor that the FDA normally would apply,&#8221; she says.<\/p>\n<p>Halladay adds the White House&#8217;s messaging further confused many families when Mehmet Oz, head of the federal agency that oversees Medicare and Medicaid, promised at the news conference that state Medicaid programs &#8220;will cover prescription leucovorin around the country,&#8221; adding that &#8220;it&#8217;s yours, but you have to go to a doctor and get a prescription.&#8221;<\/p>\n<p>&#8220;It was disingenuous to tell people at the press conference that it was going to be made available to everybody,&#8221; Halladay said. She says the language issued later shows it will allow leucovorin prescriptions only for that subset of autistic patients with CFD, the vitamin B deficiency.<\/p>\n<aside id=\"ad-overflow-4-wrap\" class=\"ad-wrap overflow-4\" aria-label=\"advertisement\">\n<\/aside>\n<p>&#8220;I think families should know that, in fact, it&#8217;s not going to be approved or made available to the wide autism community; it&#8217;s only going to be made available to those with a documented cerebral folate deficiency,&#8221; Halladay said.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The Trump administration has suggested that leucovorin, a drug used in cancer treatment, might have some benefit for children with autism. Many researchers and families aren&#8217;t so sure. Andrew Harnik\/Getty Images hide caption toggle caption Andrew Harnik\/Getty Images President Trump is promising a new treatment for autism spectrum disorder: a prescription form of vitamin B9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4536,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[327],"tags":[1580,1685,928,895,411,1686],"class_list":{"0":"post-4535","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-autism","9":"tag-leucovorin","10":"tag-parents","11":"tag-scientists","12":"tag-shots","13":"tag-skeptical"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.0 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Leucovorin for autism? 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