{"id":5222,"date":"2025-11-21T04:00:54","date_gmt":"2025-11-21T12:00:54","guid":{"rendered":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/"},"modified":"2025-11-21T04:01:00","modified_gmt":"2025-11-21T12:01:00","slug":"brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots","status":"publish","type":"post","link":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/","title":{"rendered":"Brain scientists are seeking weight-loss drugs without the nausea : Shots"},"content":{"rendered":"<p><\/p>\n<div id=\"storytext\">\n<div id=\"resg-s1-98639\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 8192;&#10;        --source-height: 5464;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/400\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/900\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/1200\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/1600\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/1800\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/400\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 400w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 800w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/900\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 900w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/1200\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 1200w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/1600\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 1600w,&#10;https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/1800\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg 1800w\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/8192x5464+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fb4%2F87%2F259ad87d4bc68a43bd37a48252a0%2Fgettyimages-2195158078.jpg\" sizes=\"(min-width: 1025px) 650px, calc(100vw - 30px)\" class=\"img\" type=\"image\/jpeg\"\/><\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                Many people who take GLP-1 drugs like Wegovy and Zepbound for weight loss experience unpleasant side effects. Brain scientists are trying to find ways to avoid them. <br \/><b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    blackCAT\/Getty Images\/E+<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        blackCAT\/Getty Images\/E+<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>Millions of Americans have shed pounds with help from drugs like Wegovy and Zepbound.<\/p>\n<p>But people who take these drugs often experience unpleasant side effects.<\/p>\n<div id=\"resnx-s1-5615168-100\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImagenx-s1-5225375\" href=\"https:\/\/www.npr.org\/2024\/12\/12\/nx-s1-5225375\/these-neurons-in-the-abdomen-help-form-the-gut-brain-connection\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/2024\/12\/12\/nx-s1-5225375\/these-neurons-in-the-abdomen-help-form-the-gut-brain-connection&quot;}\"><picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1456x1456+449+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fc7%2F9c%2F550ce50f4ea5bc551cf4478af263%2Fgettyimages-1372478419.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"Scientists have identified two types of brain cells in the abdomen that appear to control different aspects of digestion.\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5615168-100\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>&#8220;They lose weight, which is a positive thing,&#8221; says <a href=\"https:\/\/medschool.umich.edu\/profile\/warren-yacawych\" target=\"_blank\"><u>Warren Yacawych<\/u><\/a> of the University of Michigan, &#8220;but they experience such severe nausea and vomiting that patients stop treatment.&#8221;<\/p>\n<p>So at this year&#8217;s Society for Neuroscience meeting in San Diego, Yacawych and other researchers held a session to describe their efforts to understand and solve the side-effect problem.<\/p>\n<p>The weight-loss products are called <a href=\"https:\/\/www.npr.org\/sections\/shots-health-news\/2025\/10\/28\/nx-s1-5587805\/glp-1-ozempic-zepbound-gallup-obesity-rate\" target=\"_blank\"><u>GLP-1 agonists<\/u><\/a>. They work by mimicking a hormone that reduces appetite and slows digestion.<\/p>\n<p>Yacawych and his colleagues wanted to know if they could tweak these drugs to suppress appetite without making people queasy.<\/p>\n<aside id=\"ad-backstage-wrap\" class=\"ad-wrap backstage\" aria-label=\"advertisement\">\n<\/aside>\n<div id=\"resnx-s1-5615168-101\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage1214558929\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2023\/11\/23\/1214558929\/salty-much-these-brain-cells-decide-when-tasty-becomes-blech\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/health-shots\/2023\/11\/23\/1214558929\/salty-much-these-brain-cells-decide-when-tasty-becomes-blech&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2023\/11\/22\/gettyimages-1314366525_sq-b9f9ae1b79bdf0ecbeff424099ee1c0246efe1fa.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"Salty much? These brain cells decide when tasty becomes blech\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5615168-101\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>The team focused on two areas in the brain stem where GLP-1 drugs have a big effect.<\/p>\n<p>&#8220;The first is affectionately known as the brain stem&#8217;s vomit center,&#8221; Yacawych says. &#8220;It&#8217;s naturally designed to detect any accidentally ingested toxin and coordinate the feeling of nausea and the vomit response.&#8221;<\/p>\n<p>The second area monitors food intake and tells people when they&#8217;re full.<\/p>\n<p>The team found a way to direct GLP-1 to the area involved in feeling full, while keeping the drug out of the vomit center.<\/p>\n<p>When the researchers did this, the mice no longer felt sick. But they also didn&#8217;t get thin \u2014 probably because there are specific cells in the vomit center that do not induce vomiting but are critical to weight loss.<\/p>\n<p>&#8220;So it&#8217;s very challenging,&#8221; Yacawych says, &#8220;to be able to separate these side effects, like nausea, from GLP-1&#8217;s intended effects, like weight loss.&#8221;<\/p>\n<p>A possible workaround came from a team led by <a href=\"https:\/\/endocrinology.uw.edu\/people\/faculty\/blevins-j\" target=\"_blank\"><u>Ernie Blevins<\/u><\/a> of the University of Washington. They gave obese rats a low dose of a GLP-1 drug along with the hormone <a href=\"https:\/\/www.npr.org\/2023\/01\/28\/1152313319\/a-new-study-casts-doubt-on-oxytocins-role-as-a-love-hormone\" target=\"_blank\"><u>oxytocin<\/u><\/a>, which is itself an appetite suppressant. That allowed the rats to lose weight without feeling sick.<\/p>\n<h3 class=\"edTag\">Not just nausea<\/h3>\n<p>Another side effect of GLP-1 drugs is a decrease in thirst, which could be dangerous for people who are already losing lots of fluids from side effects like vomiting and diarrhea.<\/p>\n<aside id=\"ad-secondary-wrap\" class=\"ad-wrap secondary\" aria-label=\"advertisement\">\n<\/aside>\n<p>&#8220;If you&#8217;re in that state of dehydration and you&#8217;re not feeling thirsty to replace those fluids, that would be a problem,&#8221; says <a href=\"https:\/\/arts-sciences.buffalo.edu\/biological-sciences\/faculty\/faculty-directory\/DerekDaniels.html\" target=\"_blank\"><u>Derek Daniels<\/u><\/a> of the University at Buffalo.<\/p>\n<p>To understand how GLP-1 drugs reduce thirst, Daniels and a team began studying the brains of rats. And they got lucky.<\/p>\n<div id=\"resnx-s1-5615168-102\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage1076089390\" href=\"https:\/\/www.npr.org\/sections\/health-shots\/2022\/01\/27\/1076089390\/thirsty-heres-how-your-brain-answers-that-question\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/health-shots\/2022\/01\/27\/1076089390\/thirsty-heres-how-your-brain-answers-that-question&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2022\/01\/27\/gettyimages-487151041_sq-b55069faf41efc0d4484b8025d56f4ef42a97946.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"Thirsty? Here's how your brain answers that question\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5615168-102\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>&#8220;We had a happy accident in the lab,&#8221; Daniels says. &#8220;And the happy accident involved a rat called the <a href=\"https:\/\/www.eneuro.org\/content\/3\/2\/ENEURO.0150-15.2016\" target=\"_blank\"><u>Brattleboro rat<\/u><\/a>.&#8221;<\/p>\n<p>Brattleboro rats are laboratory rodents with a genetic mutation that makes them thirsty nearly all the time. But the scientists discovered that these rats are also very sensitive to GLP-1 drugs, which drastically reduced their water consumption.<\/p>\n<p>The team studied the rats&#8217; brains to see where GLP-1 was influencing thirst. That led them to several areas of the brain that appear to affect thirst but not appetite.<\/p>\n<div id=\"resnx-s1-5615168-103\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImage589295404\" href=\"https:\/\/www.npr.org\/sections\/thesalt\/2018\/02\/28\/589295404\/still-thirsty-its-up-to-your-brain-not-your-body\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\/\/www.npr.org\/sections\/thesalt\/2018\/02\/28\/589295404\/still-thirsty-its-up-to-your-brain-not-your-body&quot;}\"><picture><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s=100&amp;c=85&amp;f=jpeg\" data-original=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s=100&amp;c=100&amp;f=jpeg\" data-template=\"https:\/\/media.npr.org\/assets\/img\/2018\/02\/27\/drinking-water-1_sq-7c97587e97e729a621fa5f6667fe473bb414c7eb.jpg?s={width}&amp;c={quality}&amp;f={format}\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"Still Thirsty? It's Up To Your Brain, Not Your Body\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5615168-103\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>The discovery could help scientists preserve thirst by designing drugs that &#8220;target good places but not bad places,&#8221; Daniels says.<\/p>\n<h3 class=\"edTag\">Appetite and addiction<\/h3>\n<p>A team from the University of Virginia found that GLP-1 drugs are already targeting a brain area that plays a role in addiction as well as eating. It&#8217;s a region involved in emotion and the reward system.<\/p>\n<p>When the researchers delivered GLP-1 to this brain area in mice, it reduced their desire for &#8220;rewarding food, like a burger,&#8221; says <a href=\"https:\/\/bio.as.virginia.edu\/people\/ali-d-guler\" target=\"_blank\"><u>Ali D. G\u00fcler<\/u><\/a> of the University of Virginia.<\/p>\n<p>But the animals continued to eat healthy, nonrewarding foods, he says \u2014 a bit like people choosing a salad bar over dessert.<\/p>\n<p>Identifying this brain area should help scientists find GLP-1 drugs that target the reward system while avoiding areas involved in appetite, G\u00fcler says. And that could lead to new treatments for alcoholism and other substance use disorders.<\/p>\n<p>The finding also could explain the observation that people who take GLP-1 agonists tend to reduce their consumption of alcohol.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Many people who take GLP-1 drugs like Wegovy and Zepbound for weight loss experience unpleasant side effects. Brain scientists are trying to find ways to avoid them. blackCAT\/Getty Images\/E+ hide caption toggle caption blackCAT\/Getty Images\/E+ Millions of Americans have shed pounds with help from drugs like Wegovy and Zepbound. But people who take these drugs [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5223,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[327],"tags":[244,767,1983,895,1981,411,1982],"class_list":{"0":"post-5222","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-brain","9":"tag-drugs","10":"tag-nausea","11":"tag-scientists","12":"tag-seeking","13":"tag-shots","14":"tag-weightloss"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.0 (Yoast SEO v26.0) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Brain scientists are seeking weight-loss drugs without the nausea : Shots - Well Rooted Wellness<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brain scientists are seeking weight-loss drugs without the nausea : Shots\" \/>\n<meta property=\"og:description\" content=\"Many people who take GLP-1 drugs like Wegovy and Zepbound for weight loss experience unpleasant side effects. Brain scientists are trying to find ways to avoid them. blackCAT\/Getty Images\/E+ hide caption toggle caption blackCAT\/Getty Images\/E+ Millions of Americans have shed pounds with help from drugs like Wegovy and Zepbound. But people who take these drugs [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/\" \/>\n<meta property=\"og:site_name\" content=\"Well Rooted Wellness\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/groups\/948985443013245\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-21T12:00:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-21T12:01:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1400\" \/>\n\t<meta property=\"og:image:height\" content=\"788\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"wrwofficial.com\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"wrwofficial.com\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/\"},\"author\":{\"name\":\"wrwofficial.com\",\"@id\":\"https:\/\/wrwofficial.com\/#\/schema\/person\/636ab349f3b686d9a710f47cc20a9f8b\"},\"headline\":\"Brain scientists are seeking weight-loss drugs without the nausea : Shots\",\"datePublished\":\"2025-11-21T12:00:54+00:00\",\"dateModified\":\"2025-11-21T12:01:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/\"},\"wordCount\":716,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/wrwofficial.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg\",\"keywords\":[\"Brain\",\"Drugs\",\"nausea\",\"scientists\",\"seeking\",\"Shots\",\"weightloss\"],\"articleSection\":[\"Health\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/\",\"url\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/\",\"name\":\"Brain scientists are seeking weight-loss drugs without the nausea : Shots - Well Rooted Wellness\",\"isPartOf\":{\"@id\":\"https:\/\/wrwofficial.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg\",\"datePublished\":\"2025-11-21T12:00:54+00:00\",\"dateModified\":\"2025-11-21T12:01:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage\",\"url\":\"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg\",\"contentUrl\":\"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg\",\"width\":1400,\"height\":788},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/wrwofficial.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Brain scientists are seeking weight-loss drugs without the nausea : Shots\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/wrwofficial.com\/#website\",\"url\":\"https:\/\/wrwofficial.com\/\",\"name\":\"Well Rooted Wellness\",\"description\":\"Improving your mind, body &amp; garden\",\"publisher\":{\"@id\":\"https:\/\/wrwofficial.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/wrwofficial.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/wrwofficial.com\/#organization\",\"name\":\"Well Rooted Wellness\",\"url\":\"https:\/\/wrwofficial.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/wrwofficial.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/04\/Well-Rooted-Wellness.png\",\"contentUrl\":\"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/04\/Well-Rooted-Wellness.png\",\"width\":1563,\"height\":1563,\"caption\":\"Well Rooted Wellness\"},\"image\":{\"@id\":\"https:\/\/wrwofficial.com\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/groups\/948985443013245\",\"https:\/\/www.instagram.com\/wellxrootedxwellness\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/wrwofficial.com\/#\/schema\/person\/636ab349f3b686d9a710f47cc20a9f8b\",\"name\":\"wrwofficial.com\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/wrwofficial.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c6ded1cbd04f143e74ecb79408439214dd2468dfcf0846364f851280c489065b?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c6ded1cbd04f143e74ecb79408439214dd2468dfcf0846364f851280c489065b?s=96&d=mm&r=g\",\"caption\":\"wrwofficial.com\"},\"sameAs\":[\"http:\/\/wrwofficial.com\"],\"url\":\"https:\/\/wrwofficial.com\/index.php\/author\/wrwofficial-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Brain scientists are seeking weight-loss drugs without the nausea : Shots - Well Rooted Wellness","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/","og_locale":"en_US","og_type":"article","og_title":"Brain scientists are seeking weight-loss drugs without the nausea : Shots","og_description":"Many people who take GLP-1 drugs like Wegovy and Zepbound for weight loss experience unpleasant side effects. Brain scientists are trying to find ways to avoid them. blackCAT\/Getty Images\/E+ hide caption toggle caption blackCAT\/Getty Images\/E+ Millions of Americans have shed pounds with help from drugs like Wegovy and Zepbound. But people who take these drugs [&hellip;]","og_url":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/","og_site_name":"Well Rooted Wellness","article_publisher":"https:\/\/www.facebook.com\/groups\/948985443013245","article_published_time":"2025-11-21T12:00:54+00:00","article_modified_time":"2025-11-21T12:01:00+00:00","og_image":[{"width":1400,"height":788,"url":"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg","type":"image\/jpeg"}],"author":"wrwofficial.com","twitter_card":"summary_large_image","twitter_misc":{"Written by":"wrwofficial.com","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#article","isPartOf":{"@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/"},"author":{"name":"wrwofficial.com","@id":"https:\/\/wrwofficial.com\/#\/schema\/person\/636ab349f3b686d9a710f47cc20a9f8b"},"headline":"Brain scientists are seeking weight-loss drugs without the nausea : Shots","datePublished":"2025-11-21T12:00:54+00:00","dateModified":"2025-11-21T12:01:00+00:00","mainEntityOfPage":{"@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/"},"wordCount":716,"commentCount":0,"publisher":{"@id":"https:\/\/wrwofficial.com\/#organization"},"image":{"@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage"},"thumbnailUrl":"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg","keywords":["Brain","Drugs","nausea","scientists","seeking","Shots","weightloss"],"articleSection":["Health"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/","url":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/","name":"Brain scientists are seeking weight-loss drugs without the nausea : Shots - Well Rooted Wellness","isPartOf":{"@id":"https:\/\/wrwofficial.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage"},"image":{"@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage"},"thumbnailUrl":"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg","datePublished":"2025-11-21T12:00:54+00:00","dateModified":"2025-11-21T12:01:00+00:00","breadcrumb":{"@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#primaryimage","url":"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg","contentUrl":"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/11\/urlhttp3A2F2Fnpr-brightspot.s3.amazonaws.com2Fb42F872F259ad87d4bc68a43bd37a48252a02Fgettyim.jpeg","width":1400,"height":788},{"@type":"BreadcrumbList","@id":"https:\/\/wrwofficial.com\/index.php\/2025\/11\/21\/brain-scientists-are-seeking-weight-loss-drugs-without-the-nausea-shots\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/wrwofficial.com\/"},{"@type":"ListItem","position":2,"name":"Brain scientists are seeking weight-loss drugs without the nausea : Shots"}]},{"@type":"WebSite","@id":"https:\/\/wrwofficial.com\/#website","url":"https:\/\/wrwofficial.com\/","name":"Well Rooted Wellness","description":"Improving your mind, body &amp; garden","publisher":{"@id":"https:\/\/wrwofficial.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/wrwofficial.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/wrwofficial.com\/#organization","name":"Well Rooted Wellness","url":"https:\/\/wrwofficial.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/wrwofficial.com\/#\/schema\/logo\/image\/","url":"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/04\/Well-Rooted-Wellness.png","contentUrl":"https:\/\/wrwofficial.com\/wp-content\/uploads\/2025\/04\/Well-Rooted-Wellness.png","width":1563,"height":1563,"caption":"Well Rooted Wellness"},"image":{"@id":"https:\/\/wrwofficial.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/groups\/948985443013245","https:\/\/www.instagram.com\/wellxrootedxwellness"]},{"@type":"Person","@id":"https:\/\/wrwofficial.com\/#\/schema\/person\/636ab349f3b686d9a710f47cc20a9f8b","name":"wrwofficial.com","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/wrwofficial.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c6ded1cbd04f143e74ecb79408439214dd2468dfcf0846364f851280c489065b?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c6ded1cbd04f143e74ecb79408439214dd2468dfcf0846364f851280c489065b?s=96&d=mm&r=g","caption":"wrwofficial.com"},"sameAs":["http:\/\/wrwofficial.com"],"url":"https:\/\/wrwofficial.com\/index.php\/author\/wrwofficial-com\/"}]}},"_links":{"self":[{"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/posts\/5222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/comments?post=5222"}],"version-history":[{"count":1,"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/posts\/5222\/revisions"}],"predecessor-version":[{"id":5224,"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/posts\/5222\/revisions\/5224"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/media\/5223"}],"wp:attachment":[{"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/media?parent=5222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/categories?post=5222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wrwofficial.com\/index.php\/wp-json\/wp\/v2\/tags?post=5222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}